An Apostrophe About Brain Chemistry

So there are these cannabinoid receptor thingies in your brain, and when you smoke enough, they get clogged or tired out (conceptually, anyway) and you start developing a tolerance.

Now here’s the interesting part.

Before I started using MMJ, I had an almost constant “fogginess” in my head (there’s really not much of a better way to describe it). After much experimentation, which has been covered here, I found that a small amount of Sour Diesel several times a day would keep this fogginess away and help my concentration, mood, depression, blood pressure, and a few other things.

However, after about five weeks of this treatment, I noticed an odd effect. Sour Diesel wasn’t working properly any more. In fact, I was getting the old “fogginess” back after using it, which had never happened before (and yes, it’s the same batch). So I tried a few other strains. Lo and behold, almost any other strain I tried seemed to banish the fog (although they weren’t all equally good at the other problems).

By now, pretty much everyone who’s tried multiple strains of marijuana know that they have different effects (imagine if different brands of beer or liquor had wildly different effects!). So here’s my theory: the different strains have different cannabinoids, which affect different receptors, which cause different effects. And if one strain, used repeatedly, causes its receptors to shut down due to tolerance effects, that explains why switching to a different strain allows your body to respond again.

But wait, there’s more.

Since the “fog” created by using the tolerance-bound strain (for lack of a better term) seems to be similar to the “fog” of depression, doesn’t it make sense that one of the aspects of depression (if not the cause!) is that brain chemistry is also overloading receptors somewhere? That’s perhaps the difference between true depression and the “Wow, man, I’m so depressed, we had a pop quiz at school today” stuff. Only true depression goes on long enough that your body is going to build up a tolerance to these chemicals (whatever they are), and the tolerance itself, or the overloaded receptors, is the true direct cause of the fogged feeling.

More research is clearly needed here, and of course I don’t pretend to be a neurochemistry expert, even on the web, but if this gives some insight to one of those folks…that’s why I wrote this.

About Old Hippie Old Hippie is a father of two boys and thankfully living in California where all this kind of thing is legal. He started smoking marijuana in 1967 in high school, experimented with mind-expanding drugs of all kinds, and then straightened out 15 or so years later to become an airplane pilot. After being diagnosed with depression in 2000, he lost his job and most of the following decade to prescription medications (such as antidepressants) which sapped his energy and will. Finally, a chance conversation with a friend led to a doctor’s recommendation for medical marijuana (MMJ). This changed his entire life, health, and outlook for the better. is his continuing story. It’s also his way to provide experienced advice on using medical marijuana effectively and responsibly, as well as advocacy, activism, and support for others. Old Hippie teaches about safe use of cannabis edibles, Canna Caps, vaporizers, dosing, and even microdosing.


It must be different for different people as well…because I used sour diesel once after having quit for a while and it GAVE me the “foggy” effect you describe, something I don’t usually have as you seem to. That’s why I don’t like sour diesel

Leave a Reply